All about multiple sclerosis
Multiple sclerosis, is an autoimmune disease. The immune system in humans is designed to protect the body from the ill effects of foreign invaders like viruses, bacteria, fungi, and pollens that can cause harm to the body. For some unknown and not fully understood reasons, the immune system becomes hyperactive and attacks one system or the other of the human body. Depending on the system affected, there are different names for the condition. However, all autoimmune diseases have the common trait of periodic flare ups alternating between periods of relative quiets or remittance. There is considerable variation in the symptoms multiple sclerosis and their intensity and is almost specific to each of the patients.
Multiple Sclerosis is an autoimmune disorder with a faulty immune system where the nerves of the central nervous system, the brain and spinal cord are potentially disabled. The protective sheath of the nerves, called as the myelin layer, is attacked and destroyed. This causes problems in the communication between the brain and the rest of the body. As the disease progresses the nerves themselves deteriorate or permanently damaged
The symptoms of multiple sclerosis, as is with autoimmune diseases, vary considerably in patients. The symptoms of multiple sclerosis enumerated below should be viewed with that perspective in mind. Early symptoms of multiple sclerosis can be any or any combination of the following:
These early symptoms of multiple sclerosis progress into a cycle of acute exacerbations. Symptoms of multiple sclerosis flare up for a particular period followed by a period of quietude during which the severity of symptoms of multiple sclerosis decrease and sometimes totally disappear. In about 60 to 70% of patients, the symptoms of multiple sclerosis progress to a steady stage of the disease with or without the remittance. This type of disease progression is called secondary progressive MS. There are also times when the early symptoms of multiple sclerosis just steadily become more and more severe and extensive without the periods of remittance. This type is called primary progressive MS.
Multiple Sclerosis is an autoimmune disease and has no known cause. However, a combination of genetics and environmental factors certainly contribute to its development.
Diagnosis and treatment
There are no specific diagnostic tests for MS. Most part of the diagnosis is the symptom picture and history. Some test like blood and spinal fluid tests are used to eliminate diseases with similar symptoms to that of multiple sclerosis. Test for a specific marker in blood is under development. Brain MRI can show lesions on brain and spinal cord. Evoked potential test shows how fast signals produced due to specific stimuli travels down the spinal cord.
In current knowledge, there are avenues available for treatments of multiple sclerosis, though there is no cure. Treatment needs to be fine tuned frequently to suite the conditions of the patient. In the former category are corticosteroids and plasma exchange when steroids have proved ineffective. In the latter category of treatments for multiple sclerosis, there is the drug called ocrelizumab. This medicine is the only one with FDA approval, and is made for treating primary progressive multiple sclerosis, although debilitating a near normal life for long periods is possible now.